Smart Drug Delivery

Recent advances in biotechnology yield myriads of promising drug candidates with delicate molecular structure but poor bioavailability. The challenge is to manufacture smart delivery systems which protect but also release the drug at the desired site of action and/or absorption. Ongoing from recent knowledge collected about the basic mechanisms of the lectin-cell interaction, wheat germ agglutinin-grafted and labelled biodegradable micro- and nanoparticles as well as soluble macromolecular prodrug-systems are being characterised in terms of their capacity to mediate mucoadhesion, cytoadhesion, cytoinvasion, and improved transcellular transport. At this, special emphasis is given to the influence of the preparation process, the payload, and the surface modification on the characteristics of the particles. Furthermore, in collaboration with groups from the University of Vienna, the Medical University, the Technical University of Vienna, the Biophysics group at the University of Augsburg, Eindhoven Technical University, and industrial partners, the utility of birch- and grass pollen loaded microparticles for treatment of allergies, the concept of re-loading scaffolds with drug-containing nanoparticles exploiting biorecognition, the interaction of lectinised nanoparticles with human artificial intestinal tissue under flow conditions, the influence of surfactants on the nanoparticle cell-interaction, and the potential of Gadolinium-loaded nanoparticles for diagnostic purposes is being investigated.

Methods


HPLC, field flow fractionation, high shear homogenisation, ultrafiltration, atomic force microscopy, fluorescence microscopy and staining techniques, flow cytometry, dynamic light scattering, zeta potential determination, human cell culture models

Funding


1997 - 1999
OENB Nr. 65 96
Einfluss der Herstellungsparameter
auf die Größencharakteristik und das Freigabeprofil von wirkstoffhältigen
Poly-(d, l-actid-co-glycolid) Mikrosphären
1999 - 2002
FWF - P - 13513 MED
Accelerated drug development by real time kinetic studies
2004
FFG - Nr. 80 83 89

Nahrungsergänzungsmittel
zur Behebung der Histaminintoleranz
2004 - 2008
EU - FP6

CellPROM - Cell programming by nanoscaled devices
2007 - 2008
FFG - Nr. 816418

A formulation containing Xyloseisomerase
2008 - 2009
FFG - Nr. 819695
Caricol Resorption